英文名称:6-[(4R,7S)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]hexanoic acid
- Identification
Reaxys ID: 19421335 Chemical Names: 6-(3,5-dioxo-4-azatricyclo[5.2.1.02-endo,6-endo]dec-8-en-4-yl)hexanoic acid CAS Registry Number(s): 535960-53-3, 537656-33-0 Substance type: Molecular Formula: C15H19NO4 Linear Structure Formula: C15H19NO4 Molecular Weight: 277.32 No of references: 1 InChIKey: JAWZRFZAOPGTPT-NIFPGPBJSA-N
参考路线:
A round-bottom flask was charged with cis-5-norbornene-exo-2,3-dicarboxylic anhydride (4.0 g, 24.3 mmol) and 6- aminohexanoic acid (3.3 g, 25.3 mmol). To the solid mixture was added benzene (50 mL) and Et3N (410 μL, 2.92 mmol). The flask was fitted with a Dean-Stark trap and heated to reflux for 4 h. The mixture was then allowed to cool to room temperature and concentrated. The reaction mixture was diluted with CH2Cl2 (50 mL) and washed with 1 M aqueous HCl (2 × 20 mL). The organic layer was washed with saturated aqueous NaCl (20 mL), dried (Na2SO4), filtered, and concentrated under reduced pressure to provide S2 (6.35 g, 94%) as a white solid that was used without further purification