25382-33-6;93657-94-4;93947-38-7，中间5个，7个，8个碳的分别需要1g；5g

• Identification

  Reaxys ID:	192623
  Chemical Names:	1,7-bis(4-pyridyl)heptane, 4,4′-heptane-1,7-diyl-bis-pyridine, 1,7-di-[4]pyridyl-heptane, 1,7-Di-[4]pyridyl-heptan, 1,7-Di-<pyridyl-(4)>-heptan</pyridyl-(4)>
  CAS Registry Number(s):	93657-94-4	Substance type:	heterocyclic
  Molecular Formula:	C17H22N2	Linear Structure Formula:	(NC5H4)2C7H14
  Molecular Weight:	254.375	No of references:	4
  InChIKey:	VTTLBIVDTSFVMA-UHFFFAOYSA-N

• Identification

  Reaxys ID:	201148
  Chemical Names:	4,4′-octane-1,8-diyl-bis-pyridine, 1,8-di-[4]pyridyl-octane, 1,8-Di-[4]pyridyl-octan, 1,8-Di-<pyridyl-(4)>-octan</pyridyl-(4)>
  CAS Registry Number(s):	93947-38-7	Substance type:	heterocyclic
  Molecular Formula:	C18H24N2	Linear Structure Formula:	C18H24N2
  Molecular Weight:	268.402	No of references:	5
  InChIKey:	HMMWPKMUMUPILM-UHFFFAOYSA-N

参考步骤

Synthesis of 1,n-di(pyridin-4-yl)alcane (3b-e)To a 2.0 M solution of lithium diisopropyl amide in a mixture THF/heptane/ethylbenzene (18. 3 mL, 33.52 mmol, 2.2 eq) at -78°C was added dropwise 4-picoline (4.28 mL, 33.52 mmol, 2.2 eq) and the reaction medium was stirred for 1 hours. The corresponding dibromoalcane (15.24 mmol, 1 eq) was then added at -78°C and stirred for 24 h at room temperature. Deionized water (100 mL) was added and the mixture was transferred into an extraction funnel, extracted with 3×100 mL of diethylether and dried over magnesium sulfate. The mixture of solvents was removed under reduced pressure and the product was purified by column chromatography on silica gel (eluent: CH2Cl297-92: MeOH 3-8)to afford the desired compound (79-83%).3b1H NMR (400 MHz, CDCl3) δ [ppm]= 8.33 (m, 4H), 6.93 (m, 4H), 2.43 (t, 4H), 149 (m, 4H), 1.21 (2H)13C NMR (100 MHz, CDCl3) δ [ppm]= 151.9, 149.8, 124.0, 35.3, 30.3, 29.3, 29.2