化合物简介
3-Deoxyglucosone (3DG) is a dicarbonyl sugar that is synthesized through the Maillard reaction, and is metabolized to 3-deoxyfructose and 2-keto-3-deoxygluconic acid. 3DG is a precursor for the formation of advanced glycation end-products (AGEs): 3DG rapidly reacts with protein amino groups to form AGEs such as imidazolone, pyrraline, N6-(carboxymethyl)lysine, and pentosidine. 3DG as well as AGEs play a role in the modification and cross-linking of long-lived proteins such as crystallin and collagen, contributing to diseases such as the vascular complications of diabetes, atherosclerosis, hypertension, Alzheimer’s disease, inflammation, and aging.
基本信息
- 中文名称：
- 3-葡萄糖醛酮
- 中文别名：
- 3-DEOXYGLUCOSONE
- 英文名称：
- 3-deoxyglucosone
- 英文别名：
- 3-Deoxy-D-erythro-hexosulose;
3-Deoxyglucosone;
(4S,5R)-4,5,6-trihydroxy-2-oxohexanal;
- CAS号：
- 4084-27-9
- 分子式：
- C6H10O5
- 分子量：
- 162.14100
- 精确质量：
- 162.05300
- PSA：
- 94.83000
物化性质
- 密度：
- 1.406g/cm3
- 熔点：
- 73-75ºC
- 沸点：
- 400.1ºC at 760mmHg
- 闪点：
- 209.9ºC
- 折射率：
- 1.511
- 稳定性：
- Hygroscopic
- 储存条件：
- Hygroscopic, -20ºC Freezer, Under Inert Atmosphere
安全信息
- 危险品标志：Xi
