氰酸钾与胺反应生成脲

对于没有任何取代基的脲，一般主要通过氰酸钾与胺反应得到，一般这类反应在水和醋酸的混合溶剂中进行。

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氰酸钾与胺反应生成脲示例 （J. Am. Chem. Soc.,1992 10715-10721）

To asolution of o-aminophenol (1.1 g, 10 mmol) in 20 mL of glacial acetic acid andwater (1:1) was added a solution of potassium cyanate (1.6g, 20 mmol) in waterdropwise. The resulting solution was stirred at r.t. for 3 h. After removal ofthe solvent, the residue was dissolved in EtOAc (100 mL). The organic phase waswashed with sodium bicarbonate solution and brine, dried over anhydrous Na2SO4and filtered. The filtrate was concentrated to the crude product, which was recrystallizedonce from methanol and then several times from acetone-hexane to afford 1.2 gof white needles (2-Hydroxy-phenyl)-urea (80 %).

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