芳烃与酰基化试剂如酰卤、酸酐、羧酸、烯酮等在Lewis酸(通常用无水三氯化铝)催化下发生酰基化反应，得到芳香酮：

这是制备芳香酮类最重要的方法之一，在酰基化中不发生烃基的重排。

反应机理:

反应实例:

参考文献：

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Friedel-Crafts acylation. Can. J. Chem. 1994, 72, 1656-1659.

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