中间体均可买到

4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)morpholin-3-one
Chemical Formula: C22H22ClFN4O4
Molecular Weight: 460.8904
m/z: 460.1314 (100.0%), 462.1284 (32.0%), 461.1347 (23.8%), 463.1318 (7.6%), 462.1381 (2.7%), 461.1284 (1.5%)
Elemental Analysis: C, 57.33; H, 4.81; Cl, 7.69; F, 4.12; N, 12.16; O, 13.89