化合物简介
Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial. Chemically, it is an organic compound consisting of an aniline derivatized with a sulfonamide group. Powdered sulfanilamide was used by the Allies in WWII to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to previous wars. Modern antibiotics have supplanted sulfanilamide on the battlefield; however, sulfanilamide remains in use for treatment of vaginal yeast infections.
The term “sulfanilamides” is also used to describe a family of molecules containing these functional groups. Examples include: Furosemide, a loop diuretic; Sulfadiazine, an antibiotic; Sulfamethoxazole, an antibiotic.
The term “sulfanilamides” is also used to describe a family of molecules containing these functional groups. Examples include: Furosemide, a loop diuretic; Sulfadiazine, an antibiotic; Sulfamethoxazole, an antibiotic.
基本信息
- 中文名称：
- 磺胺
- 中文别名：
- 对氨基苯磺酰胺;
4-氨基苯磺酰胺;
利鲁唑;
- 英文名称：
- sulfanilamide
- 英文别名：
- Sulphonamide;
Sulfamine;
Sulfanilamide;
Sulfonylamide;
Benzenesulfonamide, 4-amino-;
查看更多英文别名
- CAS号：
- 63-74-1
- 分子式：
- C6H8N2O2S
- 分子量：
- 172.20500
- 精确质量：
- 172.03100
- PSA：
- 94.56000
- LogP：
- 2.27850
物化性质
- 外观与性状：
- 白色至淡黄色结晶粉末
- 密度：
- 1.08
- 熔点：
- 164-166 °C(lit.)
- 沸点：
- 401ºC
- 折射率：
- 1.5897 (158ºC)
- 水溶解性：
- 7.5 g/L at 25 ºC
- 稳定性：
- Stable under normal temperatures and pressures.
- 储存条件：
- 包装完整、轻装轻放,库房通风、远离明火、高温、与氧化剂分开存放
安全信息
- 海关编码：2935009090
- WGK Germany：3
- 危险类别码：R40
- 安全说明：S24/25
- RTECS号：WO8400000
- 危险品标志：Xn
生产方法及用途
查看全部
生产方法
1.由乙酰苯胺经氯磺化、胺化、水解、中和制得。 原料消耗定额:乙酰苯胺(99%)1032kg/t、氯磺酸(96%)4521kg/t、液氨(99.8%)535kg/t、 液碱(30%)863kg/t。
用途
磺胺类药物，作为中间体应用于其他磺胺类药物和农药。
