在乙酸酐存在下酰基甘氨酸发生分子内缩合得到5-恶唑酮（吖内酯）。

反应机理：

反应实例：

参考文献：

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编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Erlenmeyer-Plöchl azlactone synthesis， page 212-213.