烯酮和烯烃进行[2 + 2]-光化学环加成后，进行反-羟醛缩合得到1,5-二酮的反应。

反应机理

底物头对尾排列进行环加成得到主要产物。

底物头对头排列进行环加成得到少量的异构体。

反应实例

参考文献

1. (a) de Mayo, P.; Takeshita, H.; Sattar, A. B. M. A. Proc. Chem. Soc., London 1962,119. Paul de Mayo received his doctorate from Sir Derek Barton at Birkbeck College, University of London. He later became a professor at the University of Western Ontario in London, Ontario, Canada, where he discovered the de Mayo reaction.[Paul de Mayo在伦敦大学伯贝克学院Derek Barton门下获得博士学位，后来出任加拿大西安大略大学教授，在那里他发现了de Mayo反应] (b) Challand, B. D.; Hikino, H.; Kornis, G.; Lange, G.; de Mayo, P. J. Org. Chem. 1969, 34, 794-806.

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11. Wu, Y.-J. Name Reactions in Carbocyclic Ring Formations, Li, J. J., Ed., Wiley: Hoboken, NJ, 2010; pp 451-488.

编译自：J.J. Li, Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications, de Mayo reaction，page 200-201.