Glaser偶联是通过两个端基炔合成对称二炔或环状二炔的常用反应。机理上与Eglinton 反应类似，不同的是此反应用一价铜作为催化剂，通过反应中加入氧气重新氧化完成催化循环。

与之类似的Hay偶联相比Glaser偶联有很多优点，此反应中用到的Cu-TMEDA络合物催化剂可以溶于很多溶剂，所以反应应用性更广。

Cadiot-Chodkiewicz 偶联可以合成非对称的二炔可以作为此反应的互补反应，很有价值。

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编译自：Organic Chemistry Portal