碱性条件下苯酚和氯仿反应生成邻甲酰基苯酚的反应。

反应机理

1，卡宾的生成

2，二氯卡宾的加成和水解

反应实例

参考文献

1. Reimer, K.; Tiemann, F. Ber. 1876, 9, 824–828.

2. Wynberg, H.; Meijer, E. W. Org. React. 1982, 28, 1–36. (Review).

3. Bird, C. W.; Brown, A. L.; Chan, C. C. Tetrahedron 1985, 41, 4685–4690.

4. Neumann, R.; Sasson, Y. Synthesis 1986, 569–570.

5. Cochran, J. C.; Melville, M. G. Synth. Commun. 1990, 20, 609–616.

6. Langlois, B. R. Tetrahedron Lett. 1991, 32, 3691–3694.

7. Jiménez, M. C.; Miranda, M. A.; Tormos, R. Tetrahedron 1995, 51, 5825–5828.

8. Jung, M. E.; Lazarova, T. I. J. Org. Chem. 1997, 62, 1553–1555.

9. Bhunia, S. C.; Patra, G. C.; Pal, S. C. Synth. Commun. 2011, 41, 3678–3682.

编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Reimer–Tiemann reaction，page 509.