硫代二甘酸二乙酯和α-二酮在碱性条件下缩合得到3,4-二取代噻吩-2,5-二甲酸酯，然后水解生成相应的酸的反应。

反应机理

反应实例

参考文献

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Gisselbrecht, J. P. Angew. Chem. Int. Ed. 1996, 35, 1520-1525.

8. Mullins, R. J.; Williams, D. R. Hinsberg Synthesis of Thiophene Derivatives. In Name Reactions in Heterocyclic Chemistry; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2005, pp

199-206. (Review).

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编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Hinsberg synthesis of thiophenes，page 314-315.