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Hantzsch吡咯合成法2019-03-02

α-卤代甲基酮,β-酮基酯和氨缩合得到吡咯的反应。

反应机理



反应实例



参考文献

1. Hantzsch, A. Ber. Dtsch. Chem. Ges. 1890, 23, 1474.

2. Hort, E. V.; Anderson, L. R. Kirk-Othmer Encycl. Chem. Technol.; 3rd Ed.; 1982, 19,

499. (Review).

3. Katritzky, A. R.; Ostercamp, D. L.; Yousaf, T. I. Tetrahedron 1987, 43, 5171.

4. Kirschke, K.; Costisella, B.; Ramm, M.; Schulz, B. J. Prakt. Chem. 1990, 332, 143.

5. Kameswaran, V.; Jiang, B. Synthesis 1997, 530.

6. Trautwein, A. W.; Sümuth, R. D.; Jung, G. Bioorg. Med. Chem. Lett. 1998, 8, 2381.

7. Ferreira, V. F.; De Souza, M. C. B. V.; Cunha, A. C.; Pereira, L. O. R.; Ferreira, M. L.

G. Org. Prep. Proced. Int. 2001, 33, 411454. (Review).

8. Matiychuk, V. S.; Martyak, R. L.; Obushak, N. D.; Ostapiuk, Yu. V.; Pidlypnyi, N. I.

Chem. Heterocyclic Compounds 2004, 40, 1218.

编译自:Name Reactions (A Collection of Detailed Reaction Mechanisms), Jie Jack Li, Hantzsch pyrrole synthesis,page283-284.

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